Concerta in Adults – Placebo Controlled Registration Trial

This study was one of two studies that were used to register Concerta for the treatment of ADHD in Adults.

401 adults with ADHD were randomly assigned to receive either placebo or Concerta (18mg, 36mg, or 72mg/day) for 5 weeks.

At the beginning of the study, they took the Conners’ Adult ADHD Rating Scale (CAARS) test, and then took the test again at the end of the 5 weeks.

The study showed statistically significant improvements in the concerta group compared to the placebo group, with dose dependent response.

There was greater improvements in the innatentive symptoms compared to the hyperactivity/impusive symptoms.

Concerta Trial.JPGMedori, R., Ramos-Quiroga, J.A., Casas, M., Kooij, J.J.S., Niemelä, A., Trott, G., Lee, E. & Buitelaar, J.K. 2008, “A Randomized, Placebo-Controlled Trial of Three Fixed Dosages of Prolonged-Release OROS Methylphenidate in Adults with Attention-Deficit/Hyperactivity Disorder”, Biological Psychiatry, vol. 63, no. 10, pp. 981-989.